Outreach at the match: a cautionary tale

John Baruch, Ulrich Kolb, Helen Fraser and Jen Heyes share some of the pitfalls they encountered when combining outreach with football; they advocate a different sort of wow factor

Steer driverless cars towards full automation

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A mosaic of eyes

Autonomous navigation is a traditional research topic in intelligent robotics and vehicles, which requires a robot to perceive its environment through onboard sensors such as cameras or laser scanners, to enable it to drive to its goal. Most research to date has focused on the development of a large and smart brain to gain autonomous capability for robots. There are three fundamental questions to be answered by an autonomous mobile robot: 1) Where am I going? 2) Where am I? and 3) How do I get there? To answer these basic questions, a robot requires a massive spatial memory and considerable computational resources to accomplish perception, localization, path planning, and control. It is not yet possible to deliver the centralized intelligence required for our real-life applications, such as autonomous ground vehicles and wheelchairs in care centers. In fact, most autonomous robots try to mimic how humans navigate, interpreting images taken by cameras and then taking decisions accordingly. They may encounter the following difficulties

The Robots are coming – the 4th Industrial Revolution: Part 1

Ye

The Robots are coming – the 4th Industrial Revolution: Part 1

Ye

The Robots are coming – the 4th Industrial Revolution: Part 2

Ye

Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells

Nucleosome positioning at transcription start sites is known to regulate gene expression by altering DNA accessibility to transcription factors; however, its role at enhancers is poorly understood. We investigated nucleosome positioning at the androgen receptor (AR) enhancers of TMPRSS2, KLK2, and KLK3/PSA in prostate cancer cells. Surprisingly, a population of enhancer modules in androgen-deprived cultures showed nucleosome-depleted regions (NDRs) in all three loci. Under androgen-deprived conditions, NDRs at the TMPRSS2 enhancer were maintained by the pioneer AR transcriptional collaborator GATA-2. Androgen treatment resulted in AR occupancy, an increased number of enhancer modules with NDRs without changes in footprint width, increased levels of histone H3 acetylation (AcH3), and dimethylation (H3K4me2) at nucleosomes flanking the NDRs. Our data suggest that, in the absence of ligand, AR enhancers exist in an equilibrium in which a percentage of modules are occupied by nucleosomes while others display NDRs. We propose that androgen treatment leads to the disruption of the equilibrium toward a nucleosome-depleted state, rather than to enhancer de novo “remodeling.” This allows the recruitment of histone modifiers, chromatin remodelers, and ultimately gene activation. The “receptive” state described here could help explain AR signaling activation under very low ligand concentrations

Consonant mutation in Nzema and Esahie

This study examines consonant mutation particularly in Esahie[1] and Nzema. The reason for the study arises from the mutuality in the two languages. Again, previous studies have superficially treated this subject in the separate languages. However, the subject of consonant mutation is common in the above languages, yet the prevailing characteristics of the phenomenon are similar and dissimilar in the languages. Thus, this study compares and contrast consonant mutation in the two related languages to establish a correlation. In this vein, it discusses the mutational pattern, directionalities and voicing. Data for this study are assembled from four native speakers of each of the languages and literature of the respective languages. The data are analysed within the purview of Distinctive Feature Theory. The study identifies evidence to the relational effect that, the phonological environments in which the various realizations of mutation occurs also results in a harmony system. However, they differ in their mutational domains. The featural agreement normally forges between the vowel-consonant. Again, it is observed in Nzema and Esahie that, the common feature responsible for mutation in the alternant pairs, [k/x] and [k/g] is [dorsal]; [d/l] and [d/n] is [coronal]; [ʨ/ɕ] is [+strident] and [b/m] is [labial]. In both languages, harmonic assimilation is bidirectional. [1] Esahie is also known as Sefwi, Sehwi, or Asahyue. In Ghana, the language is classified as part of the linguistic Akan group of the larger Akan dialects, even though it shares very close intelligibility with Nzema (a solely ethnographic Akan) than Twi and Mfantse (which are both linguistic and ethnographic Akan). Therefore, in this paper, we shall refer to both variants as separate languages

What Happens When Mediation is Institutionalized?: To the Parties, Practitioners, and Host Institutions

The Alternative Dispute Resolution Section of the Association of American Law Schools presented a program, at the 1994 AALS Conference, on the institutionalization of mediation – through courtconnected programs and otherwise. The topic is an important one, because this phenomenon has become increasingly common in recent years. Moreover, the topic seemed especially appropriate for the 1994 program, since Florida – the host state for the conference – was one of the first states to adopt a comprehensive statute providing for court-ordered mediation (at the trial judge\u27s option) in civil disputes of all kinds. The move toward institutionalizing mediation has raised many questions, and this program was designed to highlight those questions, and provoke this discussion about them. The panel for the program was composed of mediation scholars, teachers and practitioners, from eight diverse jurisdictions around the country, with expertise on many different aspects of the institutionalization issue. The program was organized by Professor Baruch Bush (Program Chair), together with Professor Carol Liebman (Section Chair) and Dean James Alfini (Panel Moderator). This article presents an edited transcript of the panelists\u27 comments

Observed photodetachment in parallel electric and magnetic fields

We investigate photodetachment from negative ions in a homogeneous 1.0-T magnetic field and a parallel electric field of approximately 10 V/cm. A theoretical model for detachment in combined fields is presented. Calculations show that a field of 10 V/cm or more should considerably diminish the Landau structure in the detachment cross section. The ions are produced and stored in a Penning ion trap and illuminated by a single-mode dye laser. We present preliminary results for detachment from S- showing qualitative agreement with the model. Future directions of the work are also discussed.Comment: Nine pages, five figures, minor revisions showing final publicatio